Fabric Enterprise 6.10 - Release Notes

Charlene Son-Rigby -

On Wednesday March 12, 2021, Fabric Genomics released a major update to Fabric Enterprise. The webapp was updated from v6.9 to 6.10, customer-facing API will remain at  v1.2.6, and the annotations pipeline will be updated from 6.6.6 to 6.6.7 (there were no updates to the GEM pipeline).

 

This release brings a major new feature, Gene Cards, addresses several bugs, as well as updates to Clinvar, OMIM and Genomenon.

 

A summary of key changes to each component are listed below:

Fabric Enterprise Web App & API Updates

Web App version 6.8, API version 1.2.6

  • Reformatting of scoring module to use more screen space
  • Introduction of Gene Cards (to replace Condition-Genes)
  • Separation of b38 vs b37 workspaces (affects gene filters, gene cards, and panels)
  • Phevor update (including acknowledgement of failures)

Known Issues:

  • SV Viewer: shows different genes affected then stated as overlapped
  • SV viewer tracks are empty
  • SVs: sorting by flag does not work
  • Dismiss Variant functionality not working as expected

Bug fixes:

  • Fix fix b38 symbol loading in gene filters
  • Custom columns listed first in column sorting
  • Error when trying to export variants to be confirmed
  • Clicking on Evidence(CV) getting an error "Could not get evidence data value."
  • Phevor Ranks Do not Display (but phevor looks like it ran)

Annotation Pipeline changes

Pipeline version 6.6.7

  • Update to latest OMIM, Clinvar and Mastermind

Third-party tool Installations (GRCh37 and GRCh38)

  • No third party tools were installed or updated.

Data Source Updates (GRCh37)

  • ClinVar is now based on the 2021-03-01 release (monthly release),

including OMIM downloaded on 2021-03-17

  • MySQL meta info:: 2021-04-01
  • Genomenon was updated to version of 2021-04-02

Data Source Updates (GRCh38)

  • ClinVar is now based on the 2021-03-01 release (monthly release), 

including OMIM downloaded on 2021-03-17

  • Mysql meta info: 2021-04-12: 
  • Genomenon was updated to version of 2021-04-02

Bug fixes:

  • None

Known issues:

  • none

 

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